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The role of ovariectomy in the complex treatment of breast cancer


Author: Bacalîm Lilia
Degree:doctor of medicine
Speciality: 14.00.14 - Oncology and Radiotherapy
Year:2020
Scientific adviser: Nicolae Ghidirim
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific consultant: Larisa Sofroni
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Oncology
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 10 June, 2020 at the meeting of the Scientific Council and now it is under consideration of the National Council.

Abstract

Adobe PDF document1.17 Mb / in romanian

Thesis

CZU 618.19-006.6:618.211-089.87(043.2)

Adobe PDF document 4.10 Mb / in romanian
147 pages


Keywords

breast cancer, reproductive period, ovariectomy, complex treatment, luminal subtype, relapse/metastasis, survival

Summary

6 Annotation Bacalîm Lilia „The role of ovariectomy in the complex treatment of breast cancer” Thesis for the scientific degree of MD Chisinau, 2020 Thesis content: introduction, 4 chapters, synthesis of the obtained results, general conclusions and practical recommendations, bibliography from 160 sources, 5 annexes, 119 pages of printed text, 36 figures, 41 tables. The obtained results there were published in 19 scientific papers. Key words: breast cancer, reproductive period, ovariectomy, complex treatment, luminal subtype, relapse/metastasis, survival. Study domain: Oncology and radiotherapy. Study purpose: relapse and metastasis prevention in BC patients during reproductive and perimenopausal period by complex treatment application, determining the comparative effectiveness of surgical and chemical ovariectomy. Study objectives:  the determination of ovariectomy indication according to hormonal status of malignant tumors in BC patients;  ovariectomy role study in BC with metastasis prevention;  analysis of the laparoscopic surgical treatment advantages (ovariectomy) with laparotomic one;  comparative assessment of the surgical ovariectomy results with chemical one;  survival assesment according to luminal subtype in BC patients;  the elaboration of behaviour alghorythm of LUM A and LUM B subtype of BC patients Scientific news and originality: there were performed studies in order to prevent the relapse and metastasis relapse in BC patients during reproductive period with ER+ and/or PR+ by complex treatment using (surgical and chemical ovariectomy). The solved scientific problem: it consists of the determinations of indications to ovariectomy according to luminal subtype of the tumour, the determination of the ovariectomy role in order to prevent the appearence of relapse and metastasis and survival of the advanced stages patients, the establishment of advantages and disadvantages of different methods of complex treatment of BC patients during the reproductive period, that contributed to the method consolidation of the complex treatment of these neoplasias, allowed the increase of the survival rate of the BC patients. Theoretical importance: there were systematized the obtained results after the complex treatment for the assessment of malignant process in the surgical and chemical ovariectomy so preventing the LUM A și LUM B relapses and metastasis, contributing to the consolidation of complex treatment of these neoplastias and permiting increase survival rate of the BC patients during the reproductive period. The applicative value of the study: there were elaborated the practical recommendations in the behavior of oncologists for hormonal treatment improvement of BC patients, with elaboration of behaviour alghorythm that makes is possible to customize the treatment tactics in early and advanced stages. The using of the scientific results: the study results there were used in ourdays practice of the Breast Departments, Medical Oncology and Radiological Oncology and Consultative Diagnostic Center (CDC) within PMSI Oncological Institute. 7 LIS 6 Annotation Bacalîm Lilia „The role of ovariectomy in the complex treatment of breast cancer” Thesis for the scientific degree of MD Chisinau, 2020 Thesis content: introduction, 4 chapters, synthesis of the obtained results, general conclusions and practical recommendations, bibliography from 160 sources, 5 annexes, 119 pages of printed text, 36 figures, 41 tables. The obtained results there were published in 19 scientific papers. Key words: breast cancer, reproductive period, ovariectomy, complex treatment, luminal subtype, relapse/metastasis, survival. Study domain: Oncology and radiotherapy. Study purpose: relapse and metastasis prevention in BC patients during reproductive and perimenopausal period by complex treatment application, determining the comparative effectiveness of surgical and chemical ovariectomy. Study objectives:  the determination of ovariectomy indication according to hormonal status of malignant tumors in BC patients;  ovariectomy role study in BC with metastasis prevention;  analysis of the laparoscopic surgical treatment advantages (ovariectomy) with laparotomic one;  comparative assessment of the surgical ovariectomy results with chemical one;  survival assesment according to luminal subtype in BC patients;  the elaboration of behaviour alghorythm of LUM A and LUM B subtype of BC patients Scientific news and originality: there were performed studies in order to prevent the relapse and metastasis relapse in BC patients during reproductive period with ER+ and/or PR+ by complex treatment using (surgical and chemical ovariectomy). The solved scientific problem: it consists of the determinations of indications to ovariectomy according to luminal subtype of the tumour, the determination of the ovariectomy role in order to prevent the appearence of relapse and metastasis and survival of the advanced stages patients, the establishment of advantages and disadvantages of different methods of complex treatment of BC patients during the reproductive period, that contributed to the method consolidation of the complex treatment of these neoplasias, allowed the increase of the survival rate of the BC patients. Theoretical importance: there were systematized the obtained results after the complex treatment for the assessment of malignant process in the surgical and chemical ovariectomy so preventing the LUM A și LUM B relapses and metastasis, contributing to the consolidation of complex treatment of these neoplastias and permiting increase survival rate of the BC patients during the reproductive period. The applicative value of the study: there were elaborated the practical recommendations in the behavior of oncologists for hormonal treatment improvement of BC patients, with elaboration of behaviour alghorythm that makes is possible to customize the treatment tactics in early and advanced stages. The using of the scientific results: the study results there were used in ourdays practice of the Breast Departments, Medical Oncology and Radiological Oncology and Consultative Diagnostic Center (CDC) within PMSI Oncological Institute. 7 LIS