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Risk factors and early diagnosis in complications of congenital aortopathies in children


Author: Natalia Gavriliuc
Degree:doctor of medicine
Speciality: 14.00.09 - Pediatrics
Year:2020
Scientific advisers: Ina Palii
doctor habilitat, associate professor (docent)
Anatol Ciubotaru
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 24 June, 2020 at the meeting of the Scientific Council and now it is under consideration of the National Council.

Abstract

Adobe PDF document1.17 Mb / in romanian
Adobe PDF document1.02 Mb / in english

Thesis

CZU 616.132-007-053.1-053.2(043.2)

Adobe PDF document 5.71 Mb / in romanian
155 pages


Keywords

congenital aortopathies, children, complications

Summary

Thesis structure: it is presented on 104 pages and is divided into: introduction, literature review, 3 chapters with own results, synthesis of results, conclusions and practical recommendations. The bibliographic index cites 207 sources. Iconographic material: 37 tables, 34 figures, 5 annexes. The scientific results obtained were reflected in 21 scientific papers.

Domain of research: pediatrics and neonatology - 322.01.

Aim of research: to estimate the risk factors and the prognostic ones involved in the occurrence of complications in children with congenital aortopathies, in order to elucidate their probability and to develop an integrated early diagnosis algorithm.

Objectives of research: elucidation of the clinical-paraclinical features of children with congenital aortopathies with or without complications; studying the evolution of the morphometric parameters of the aorta in children with congenital aortopathies in order to detect in time some complications (aneurysm, dissection, aortic rupture); determination of risk and prediction factors in the occurrence of specific complications of congenital aortopathies in children; development of an integrated algorithm in order to prevent possible complications of congenital aortopathies in children.

The scientific novelty and originality. An analytical follow-up study was performed on a group of children with congenital aortopathies from the Republic of Moldova, with an evaluation of clinical-paraclinical features, aortic morphometry and its evolution, risk factors and prognostic factors in children with congenital aortopathies.

The scientific problem solved in the study: consists in highlighting all the pediatricians-cardiologists of the risk factors with potential development in children with congenital aortopathies of the following complications: aneurysm, dissection, aortic rupture.

Theoretical significance. The results of the study demonstrate the need and importance of evaluating the morphometric parameters of the aorta in children with congenital aortopathies. The applicative value of the PhD thesis. The value of early diagnosis in complications of congenital aortopathies in children has been argued.

Implementation of research findings. The study results were used within the activity of the Pediatric Cardiology Clinic of the IMPH Mother and Child Institute, Chisinau, Republic of Moldova.