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Pathogenic peculiarities of ischemic stroke in patients with metabolic syndrome

Author: Ciobanu Natalia
Degree:doctor of medicine
Speciality: 14.00.13 - Neurology
Scientific adviser: Stanislav Groppa
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific consultant: Lucia Ciobanu
doctor habilitat, associate professor (docent)
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova


The thesis was presented on the 23 December, 2020
Approved by NCAA on the 26 February, 2021


Adobe PDF document0.41 Mb / in romanian
Adobe PDF document0.57 Mb / in english


CZU [616.831-005/009.86]:616-008.9

Adobe PDF document 3.95 Mb / in romanian
166 pages


metabolic syndrome, stroke, risk factor, inflammatory cytokines, carotid arteries


Thesis structure: introduction, 5 chapters, general conclusions and recommendations, bibliography from 190 sources, 110 pages as basic text, 37 tables, 29 figures. The results obtained are published in 26 scientific works.

Field of study: neurology. The aim and objectives of the thesis target to investigate the peculiarities of metabolic syndrome in patients with ischemic stroke in relation with the markers of ischemic stroke, the ultrasonographic and biological markers of carotid atherosclerotic vascular damage and to elaborate some criteria for the outcome of cerebrovascular events in order to develop preventive therapeutic methods.

Novelty and scientific originality: the study has been conducted on the cluster of metabolic syndrome (MS) risk factors in patients with ischemic stroke with setting the relationships between the risk factors making up the MS, ischemic stroke subtype and the biological and ultrasonographic markers of carotid atherosclerotic artery disease. There were investigated the biomarkers of the cerebral ischemic damage (inflammatory cytokines, MMP-9, protein S-100) in the acute phase and their role in the prognosis of functional recovery.

The scientific problem highlight the role of MS in stroke, whose identification will contribute to the optimizations of risk stratification, early initiation of primary and secondary prophylaxis measures and treatment. There have been developed outcome criteria for stroke with recommendations related to prevention.

Theoretical significance: have been revealed the clinical-biochemicaldopplerographic particularities of the risk factors making up MS in patients with stroke, the role of cerebral biomarkers in stroke patients, there have been elaborated some criteria for the prognosis of cerebrovascular events.

Practical value: practical implementation of the criteria of International Diabetes Federation, American Heart Association, National Heart, Lung and Blood Institute in order to estimate the SM, practical use of ischemic cerebral markers and of ultrasound exam of the extra-cranial segment of carotid arteries which will facilitate the early diagnosis of its components, as well as the risk for stroke.

Implementation of the results were made in the daily practice of Neurology Nr. 2 Department, State University of Medicine and Pharmacy ,,Nicolae Testemițanu’’, Cerebrovascular Disease Department and Scientific Laboratory of Cerebrovascular Disease and Epilepsy of IMSP Institute of Emergency Medicine.