StatusThe thesis was presented on the 29 January, 2021
Approved by NCAA on the 25 June, 2021
Abstract– 1.24 Mb / in romanian
– 1.13 Mb / in english
4.72 Mb /
„Function of the mucociliary epithelium in patients with fungus ball of the maxillary sinus”
Doctoral thesis in medical sciences, Chisinau 2020
Thesis structure: the paper is presented on 122 pages of printed text, consists of introduction, 4 chapters, general conclusions, practical recommendations and bibliographic index with 260 references, includes 39 figures and 8 tables. The obtained results are published in 22 scientific papers, including 1 didactic compendium, 2 articles in ISI journals, SCOPUS and other international databases, 9 publications without co-authors and 8 publications in reviewed editions.
Keywords: fungal rhinosinusitis, fungus ball, mycological examination, microbiological examination, histopathological examination, allergy, invasive, nasal mucocilliary epithelium, optical microscopy.
Field of study and paper objectives. Fungal rhinosinusitis remains a controversial pathology despite all the studies that have been carried out in recent years, with confusing pathophysiology, incomplete knowledge of epidemiology and medical mycology. Based on the above, we set the next research purpose – prospective comparative study of microbiological, histopathological features and functionality of nasal pseudostratified ciliated epithelium in vitro in patients with maxillary fungus ball to optimize the diagnosis and treatment protocol. For achieving this goal, the following research objectives were established: the study of the morbidity rate of fungus ball of the maxillary sinus in the variety of rhinosinusal diseases; determination of the functionality of the mucociliary epithelium in vitro (optical microscopy) and histopathological characteristics in patients with fungus ball of the maxillary sinus; establishing the diversity of microbiological agents involved in the fungus ball of the maxillary sinus; development of a standardized diagnostic and treatment algorithm for patients with maxillary fungus ball.
The novelty and scientific originality of the obtained results: the analysis of the characteristic of the clinical forms and the diversity of the microbiological agents involved in the fungus ball of the maxillary sinus; estimating the importance and effectiveness of optical microscopy and histopathological examinations in the clinical approach of patients with fungus ball of the maxillary sinus; studying the evolution in dynamics of the nasal functional state and the nasal pseudostratified ciliated epithelium in vitro in patients with fungus ball of the maxillary sinus for the correct adjustment of the diagnosis and treatment protocol; proposing the criteria for conservative treatment of the fungus ball of the maxillary sinus, complementary to the surgical treatment, depending on the functionality of the mucociliary epithelium; performing monitoring on the evolution and prognosis of patients with fungus ball of the maxillary sinus, depending on the methods of conservative treatment associated with surgical treatment.
The applicative value of the paper consists in the elaboration of the standardized diagnosis and treatment algorithm for patients with fungus ball of the maxillary sinus and its implementation in the national clinical protocol.
Implementation of scientific results. The main results of the study are applied in the teaching process of the Department of Otorhinolaryngology of the Public Institution State University of Medicine and Pharmacy “Nicolae Testemitanu” and in the curative activity of the Department of Functional Surgery, Speech Therapy and Otorhinolaryngological Recovery of the Public Medical Institution “Timofei Mosneaga”.