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The epidemiology of nosocomial septic-purulent infections in hospitals with cardiosurgical ward

Author: Nastas Aliona
Degree:doctor of medicine
Speciality: 14.00.30 - Epidemiology
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova


The thesis was presented on the 25 February, 2022
Approved by NCAA on the 28 April, 2022


Adobe PDF document0.85 Mb / in romanian


CZU 616.94-022.369:616.12-089(043.2)

Adobe PDF document 4.62 Mb / in romanian
143 pages


septic-purulent nosocomial infections, nosocomial infections, epidemiological peculiarities, etiological peculiarities, microbial antibiotic resistance, socio-economic impact, determinants, epidemiological surveillance, cardiac surgery, healthcare associated infections


The paper consists of 108 pages of basic text and includes: introduction, four (4) chapters, summary of the results obtained, general conclusions and recommendations, bibliography of 136 titles, two (2) annexes and is illustrated with 32 tables and 45 figures. The obtained results are published in thirteen (13) scientific papers.

Fields of study: epidemiology, microbiology, clinical medicine.

The purpose of the research is to evaluate the epidemiological particularities of nosocomial septic-purulent infections (SPNI) in the cardiosurgical profile for the optimization of the systems of supervision and control of these infections.

Objectives of the research: (1) studying the epidemiological, etiological peculiarities and microbial antibiotic resistance of the SPNI in cardiac surgery; (2) determining the constituent components of the socio-economic damage of the in the cardiac-surgical inpatients; (3) evaluation of the determinants in the development of cardiosurgical SPNI; (4) elaboration of recommendations for the existing epidemiological surveillance and control program in nosocomial infections appropriate for cardiac-surgical patients.

Novelty and scientific originality. For the first time in the Republic of Moldova, a complex study of the epidemiology of SPNI was performed in the cardiosurgical profile; the epidemiological, etiological and antibiotic-microbial resistance peculiarities in the hospitals with cardiosurgical ward were established; the structure of direct and indirect expenditures in cardiac surgery SPNI was established; the determinants in the development of cardiosurgical SPNI were evaluated; recommendations have been developed for the existing program of epidemiological surveillance and control of the SPNI appropriate to cardiac surgery patients.

The important scientific problem solved consists of the scientific affirmation of the importance of researching the epidemiological, etiological particularity, microbial antibiotic resistance particularity of the SPNI and determinants in the cardiosurgical patients, which has allowed the optimization of the surveillance and control system of the SPNI and the prevention of these infections.

Theoretical significance: the epidemiological, etiological particularities, microbial antibiotic resistance, the structure of the direct and indirect expenses and determinants in the cardiosurgical SPNI were demonstrated. The obtained results complement the knowledge of the students, residents and doctors regarding the epidemiological, etiological peculiarities and microbial antibiotic resistance in SPNI in the hospitals with cardiosurgical ward.

Applicative value of the work: proposals have been submitted to be included in the next edition of the Guidance on supervision and control in nosocomial infections. The methodology of evaluating the direct and indirect expenses related to the cases of SPNI has been developed and proposed to be implemented in the medical practice.

Implementation of scientific results. The main results of the study were implemented within the multiprofile PHCS, NAPH, CPH in the process of training students, residents, master degree students, as well as surgeons, epidemiologists, microbiologists, infectious disease doctors and other medical workers.