Design and synthesis of biologically active compounds of 3d metals with N(4)-substituted thiosemicarbazones of 2-formylpyridine derivatives
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StatusThe thesis was presented on the 7 April, 2022Approved by NCAA on the 1 July, 2022 Abstract – 2.10 Mb / in romanian – 2.11 Mb / in englishThesisCZU 544.142.3:546.56:547.497(043)
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Keywords
thiosemicarbazones, coordination compounds, 3d metals, biological activity, FTIR NMR, single crystal X-ray diffractionSummary
Thesis consists of introduction, 3 chapters, general conclusions and recommendations, bibliographic references with 181 sources, 10 annexes, 123 pages, 70 figures, and 33 tables. The results are published in 30 scientific papers (6 articles in national journals, 1 article in an international journal, 23 theses at conferences, 2 patents and 1 patent application).
Field of study: Coordination Chemistry
The aim and objectives of the thesis: synthesis and physico-chemical characterization of some coordination compounds based on metal ions Cu(II), Ni(II), Fe(III), Co(III), Zn(II), Mn(II) with different N(4)-cyclohexyl(phenylacetamide; tert-butyl)thiosemicabazones derived from 2-formylpyridine; screening of antimicrobial and antifungal, anticancer and antioxidant activities of the synthesized coordination compounds; elucidation of the structure-activity relationship; synthesis of N(4)-cyclohexyl (phenylacetamide; tert-butyl) thiosemicabazons derived from 2-formylpyridine; synthesis of coordination compounds of Cu(II), Ni(II), Fe(III), Co(III), Zn(II), Mn(II) with N(4) -substituted thiosemicarbazones; physico-chemical characterization of the obtained organic and inorganic compounds by modern research methods: 1H, 13C, 15N NMR spectroscopy; EPR; FT-IR; UV-vis spectrophotometry; X-ray diffraction; mass spectroscopy; codunctometry in solution; elemental analysis. Investigation on the antimicrobial, antifungal and antioxidant properties of both intermediate and final compounds ; elucidation of the structure-activity relationship and the proposal of some of the synthesized compounds for the advanced study of biological activity.
The scientific novelty and originality consists in the synthesis of 55 coordination compounds, including 6 binuclear compounds and 49 mononuclear complexes. For the first time, a mechanism of the formation of coordination compounds based on copper(II) ion was proposed and the antimicrobial and antifungal properties of both intermediate and final , have been performed.
Scientific problem solved. Optimal conditions for obtaining the coordination compounds by classical synthesis methods have been established. Thiosemicarbazones functionalized with various substituents in N(4) position with increased lipophilicity have been obtained. Most of the synthesized coordination compounds show good solubility in ethanol and water.
Theoretical significance and applicative value of the paper. The thesis contributes to: the enlargment of biologically active compounds based on N(4) substituted thiosemicarbazones; identifying the influence of the central atom on biological properties; understanding the relationship between radical lipophilicity at N(4) position and 2-formylpyridine-derived thiosemicarbazones.
The applicative value of the results of this thesis consists of a series of coordination compounds with selective antimicrobial activity on gram-positive microorganisms.
Oficial Reviewers
- Nicon Ungur
doctor habilitat, associate professor (docent), Institute of Chemistry of the ASM - Vasile Lozan
doctor habilitat, associate professor (docent) - Pahonțu Elena Mihaela
doctor, profesor universitar, Universitatea de Medicină și Farmacie „Carol Davila” din București, România
Council's Members
- Ion Bulimestru, president
doctor, associate professor (docent) - Aurelian Gulea,
doctor habilitat, professor, Moldova State University - Nicon Ungur,
doctor habilitat, associate professor (docent), Institute of Chemistry of the ASM - Vasile Lozan,
doctor habilitat, associate professor (docent) - Angela Sîrbu, secretary
doctor, associate professor (docent)
Theses
