The etiopthogenic aspects of primary multiple cancer of hormone dependent organs of women
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StatusThe thesis was presented on the 30 January, 2007Approved by NCAA on the 1 March, 2007 Abstract – 0.49 Mb / in romanianThesisCZU 618.19, 618.14, 618.11, 616.44 - 006
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Keywords
risk factors, primary multiple cancer, mammary gland, thyroid gland, ovaries, tumor marker’s, receptors, hormone, screeningSummary
The present study, being dedicated to one of the most difficult branches of clinical
oncology – Primary Multiple Malignant Neoplasm’s (TMPN) of hormone dependent
organs (OHD), - generalize the results of thoroughly and complex prospective
investigations of etiopathogenic aspects of this pathologies by patients from our country.
It was established already, that risk factors can be various not only in different populations,
but can change in the same population in results of social modification, ecologic statement
etc., and possibly because of this cause the concepts directed on etiopathogenic aspects
of TМNP of OHD provoke till present time controversial discussions. That is why we
included in the study the analyses of various factors - biologic, constitutional, hereditary,
reproductive function peculiarities, associated pathologies, hormone homeostasis
peculiarities, diverse indices of immunity by patients with TMNР of OHD at diverse
localization. The investigation was done based on prospective data of 305 oncology
patients treated into IMSP Oncology Institute from Republic of Moldova in period of
2000-2005 years, which were distributed in two batches: the group I - 107 patients with
CPM of OHD : a mammary gland, uterine corpus, ovaries, thyroid gland, the right segment
of colon and II group – 198 patients with unilateral Brest cancer. That is why, in result of
the investigations we can answer definitely to the final objectives of this study. For this
we compared the risk factors with most weigh in prognoses of each polineoplasm’s
associations with unilateral process among them and with each group of polineoplasm’s.
Therefore, in primary multiple synchrony and metachrony cancer of mammary glandhave
in common the following aspects: the use of drugs that affec the adenohypophysis, SNC
affections, the increasing of ALT level, pathology of thyroid gland, the extending of first
malign process and hepatic function disorders when addressing with first cancer. However,
specific only for primary multiply synchrony cancer are: the increasing of level
CA-15.3, and alpha –amylase, high frequency of lobular cancer. For primary multiple
metachrony cancer of mammary gland the specific factors are: immunodepression,
manifested by decreasing of active T lymphocytes, early age of addressing with I cancer
and high frequency of genetic factor, compared with CU of MG. For Brest cancer
associated with malignant process of localization are characteristic the same common
factors for synchrony and metachrony Brest cancer: the increasing of ALT level, the
using of drugs that affect the adenohypophysis, the high of level CA-15.3, high frequency
of lobular cancer and in the same time appearance of new factors, which contribute to
central hormonal disorders – the increasing of FSH level and increasing of frequency of
renal pathology.
Oficial Reviewers
- Nicodim Belev
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Oncology - Valentin Friptu
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova - Laktionov K.
doctor habilitat în medicină, prof. universitar,, Centrul Ştiinţific Oncologic „N. N. Blohin” (Federaţia Rusă)
Theses
