StatusThe thesis was presented on the 12 July, 2013
Approved by NCAA on the 3 October, 2013
Abstract– 2.22 Mb / in romanian
4.59 Mb /
The thesis is presented in 123 text and includes general references, 4 chapters, conclusions, practical recommendations, and bibliography from 313 scientific articles. The thesis is illustrated with 38 tables and 9 figures.
Field of study:diagnosis and treatment of the BC.
Purpose of study: The main goal of thesis is to study the risk factors and estimation of clinical and biological particularities of mammary gland factors for women in menopause. For accomplishing the task were taken in consideration the following objectives: the study of weight of risk factors – social, genetic, constitutional, concomitant pathology – in the summary risk in BC at women in menopause; characteristic of metabolic disturbances of the women patients with BC; characteristic of hormonal homeostasis of the women patients with BC; complex study of immunological status – cellular and humoral – at the women patients with BC; characteristic of steroid hormone receptors in ReEs and RePg tumour, at the women patients with BC; estimate priority risk factors in triggering BC at women in menopause.
The novelty and scientific originality: the nature and frequency of factors - social, hereditary, comorbidity - BC in menopause; the significance of risk factors in BC is very large in the modern period, based on a clinical material for the first time; we have studied the different weight risks factors – exogenous and endogenous – in the appearance to the BC patients in menopause; it will make a comprehensive assessment of the particularities of homeostasis – metabolic, hormonal and immunological; for the first time will be studied hormone receptor expression - ReEs and RePg in the tumor of mammary gland cancer to the women patients in menopause, in the Republic of Moldova.
The solved scientific problem was to determine clinical and biological characteristic of breast cancer in the patients correlated with menopausal hormonal and immune status, the markers CEA, CA15.3, receptor expression Es, Pg and allows optimizing the treatment (surgery, chemotherapy and radiotherapy), which in turn improves remote results. Theoretical significance: Knowledge supplement is to study the risk factors and estimation of clinical and biological particularities of BC factors for women in menopause, level and type of immunological and hormonal deviations, the expression of molecular markers CEA,CA15.3 and RE and RP.
Practical value of the study: Based on research, will argue importance of complex examining of patients with BC in menopause and will determine the methods of investigation. Establishing these particularities will allow: