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CNAA / Theses / 2007 / May /

The immunoreglatory activity of the preparation BioR on treatment of lung tubercular patients


Author: Albina Brumaru
Degree:doctor of medicine
Speciality: 14.00.36 - Laboratorial Diagnostics; Immunology and Alergology
Year:2007
Scientific adviser: Serghei Ghindă
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Phthisiopneumology "Chiril Draganiuc"
Scientific consultant: Constantin Iavorschi
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Phthisiopneumology "Chiril Draganiuc"
Institution: Public Medical Sanitary Intitution Institute of Phthisiopneumology "Chiril Draganiuc"

Status

The thesis was presented on the 22 May, 2007
Approved by NCAA on the 14 June, 2007

Abstract

Adobe PDF document0.25 Mb / in romanian

Keywords

Clinical imunology, immunomodulator BioR, immunosupression, immunostimulation, antigen, the immune reactivity, natural resistance, immunodiagnosticare, lung tuberculosis

Summary

In the study are exposed results and the analysis of activity of the new immunoregulatory medicine BIOR in capsules, 5 mg each, on the immunological reactivity and natural resistence to patients with pulmonary tuberculosis.

They were examined 207 pacients of both sexes and different ages, and 50 healthy persons (laboratory control).

It was established the medicine BIOR in capsulses 5 mg each is an adaptogene of vegetable origine and rends a complicate immunocorrective action on breached parameters of immunological reactivity and natural resistance - the lowed parameters rase just to normal values and there heightened – reduce just to normal values.

The immunocorrective action the medicine BIOR realizes, influencing the metabolism of immunocompetent cells: normalizes the energetic metabolism of lymphocytes and functions of neutrophil oxidative - reactivation enzymes.

The medicine BIOR rends an immunocorrective influence in tuberculosis in a higher degree then the medicine PIMI-stimuline 3. This fact permits to recommend immunocorrective adaptogene BIOR for the rise of effectiveness of antituberculous therapy.

The medicine BIOR rends an immunocorrective influence in tuberculosis in different degree, in dependence on index of immunological reactivity or natural resistance and on damage degree of each concrete index.

The number of treatment courses, necessary for the normalization of index, depends on it: the more higher damage degree of explored index needs more courses of treatment for its normalization.

The medicine BIOR rends a immunocorrective influence in drug sensitive tuberculosis and drug resistant pulmonary tuberculosis. This fact permits to recommend the immunocorrective adaptogene BIOR for the rise of effectiveness of antituberculous therapy in both drug sensitive and drug resistant pulmonary tuberculosis.