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CNAA / Theses / 2007 / June /

Change of clinical and physiological parameters under influence of active oxygen in complex intensive therapy in acute cerebral ischemia

Author: Galadiuc Dorin
Degree:doctor of medicine
Speciality: 14.00.37 - Anaesthesiology and Reanimathology
Scientific adviser: Boris (decedat) Pîrgari
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific council:


The thesis was presented on the 13 June, 2007
Approved by NCAA on the 20 September, 2007


Adobe PDF document0.19 Mb / in romanian


CZU 616.831-005.4-036.11+612.014+616-089.5

Adobe PDF document 0.83 Mb / in romanian
107 pages


acute ischemia a brain, lipide peroxydation, antioxydante protection system, оxydative stress, the vegetative status, оzonotherapy


Dissertational work is devoted to studying оxydative stress and the neurovegetative status under influence of medical ozone in complex intensive therapy of the sharp period of ischemic defeat of a brain. The condition of system the LPO - AOS and the neurovegetative status at 103 patients by a sharp heart attack of the brain, taking place on treatment in intensive care branch SCM « Sf. Treime » and in intensive care branch SR Edinet during the period with 2002-2006, which have been divided into 3 groups depending on the lead treatment is investigated:

From them 31 patients traditional intensive therapy of a heart attack of a brain was carried out. At 36 pacients in complex intensive therapy with antioxydative purpose has been used ozonized physiological solution, diuring 4-5 days.

The third group was made by 36 patients at whom in complex intensive therapy with antioxydative the purpose it has been used ozonized аutohemotransfuzion.

Dynamic monitoring parameters the Lipides Peroxidation (dialdehides malonicas, lipides hydroperoxides in haematia and in plasma of blood, by the general antioxydative activity of plasma of blood) is lead, and also parameters of Antioxydative Sistem (superoxydismutase, catalaze, glutationperoxydaze, the general аntioxydative activity in haematia and in plasma of blood, activity, ceruloplasmine plasmas of blood), ABE, lipides and haemostases the status, in parallel with it were studied parameters central hemodinamix and the neurovegetatives status. The data compared both between groups of patients, and to similar parameters of control group. It is proved, that activation the Lipides Peroxidation and Antioxydative Sistem reduction of activity the proved pathogenetic part of a sharp ischemia of a brain.

The lead researches, have authentically shown expediency of inclusion of medical ozone as an ozonized physiological solution and ozonized autohemotransfuzion in complex intensive therapy of patients with a sharp ischemia of a brain.