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StatusThe thesis was presented on the 27 November, 2007Approved by NCAA on the 20 December, 2007 Abstract– 0.73 Mb / in romanianThesisCZU 616.995.1-08:636.22/28(478) 1.21 Mb / in romanian171 pages |
It has been studied the extensivity of the invasion (EI) and the intensity of the same invasion in cattle’s organism in Republic of Moldova and the changes of morpho-functional indexes (the protrombin index, the time of activated recalcification, the time of partially activated tromboplastine, the time of thrombin, the content of the fibrinogen, the level of Ca ions, the total proteins, albumins, globulins: α1, α2, β, γ, the number of leukocytes and their formula) in the cattle organism mono- and poliparasitated and after atiparasitic treatment.
The cattle parasite fauna is varying depending on the age: in calf (2-6 months old) the EI by S.papillosus was of 44,0%, Neoascaris vitulorum – 53%, Eimeria spp. – 60%, and the mixed EI constituted 68%, while in young cattle (12-18 months old) the EI by S. papillosus was of 44,0 %, N. vitulorum – 4,8%, F. hepatica – 38%, D. lanceolatum – 58%, Eimeria spp.- 58%, the mixed EI reached the level of 98,0%. In adult cattle the EI by S. papillosus was 28%, E.granulosus larvae – 60,1%, F. hepatica – 46%, D. lanceolatum – 63%, Eimeria spp. – 36,0%, the mixed EI was 100%.
The morpho-functional modifications in the poliparasitated cattle organism are more profound by comparing with the same modification in the cases of monoparasitism. At Strongiloidosis and Dicroceliosis it can be observed a tendency of hypocoagulability that is manifested by the insignificant decreasing of protrombine index, of Ca2+ ion level with the TRA, TTPa and TT prolongation due, probable, to K hypovitaminosis, to the deficit of coagulation plasmatic factors and to the presence of trombine inhibitors (hialuronidase). The strongiloidosis is characterized by the modifications of the type I proteinogram, specific for the acute inflammatory process. These deviations are confirmed also by the increased level of the fibrinogen, of the leukocyte number and of the nonsegmented cells. The electric foregram modifications in dicroceliosis are specific for the hepatic symptomatic complex: mechanical ycteris, cholecystitis, colangitis etc. The parasitic association between S. papillosus and D. lanceolatum provoce in the host-organism a significant decreasing of the protrombine index, probable, because of the accumulation of the gastroenteropulmonar pathogenetic affections and hepatic damages, which disturb the hepatic synthesis of the proteins, including the coagulation factors, while the fibrinogen and nonsegmented cell increasing indicate the presence of the acute faze of parasitic and infection level inflammations. At the same time the increasing of eosinophil number was established because of the toxic and allergenic metabolites of parasitic level, and the diminishing of the lymphocyte number is provoked by the decreasing of the infected organism immunologic reaction. The parasitic complex (Eimeria spp. S. papillosus, D. lanceolatum, E. granulosus larvae) induce a totality of plasmatic hemostasis modifications expressed by the significant decreasing of the protrombine index, extension of TRA, TTPa and TT indexes and the obvious increasing of the fibrinogen. The proteinogram modifications are characterized by the specific deviations of acute inflammatory process, which is chronic for the hepatic symptomatic complex. The morpho-functional indexes in the infected by S. papillosus animals and treated with Avomec and Tilozin 200, in the 56th day post-therapeutically re-establish under the level of the control group in percent of about 67,0%, while after complex treatment the with Umbelicen, Avomec and Tilozin 200 the studied morphofunctional indexes re-establish in proportion of about 95,0%. In the infected by D. lanceolatum cattle and treated with Rombendazol 2,5% and Tilozin 200, post-therapeutically the morpho-functional indexes re-establish in a more reduced percent, about 44,0%, probable, due to the profound hepatic damages. After the complex antiparasite treatment with Umbelicen, Rombendasol 2,5% and Tilozin 200, the studied indexes re-establish under the control group level in proportion of 91,0%. The treatment with Rombendasol 2,5% and Tilozin 200 of the infected animals by the parasite association S. papillosus and D. lanceolatum re-establish the morpho-functional status in the last stage of the experiment by about 28,0%, but as result of the complex antiparasite treatment with Umbelicen, Rombendasol 2,5% and Tilozin 200 the recovering of the morpho-functional indexes is of about 87,0%. As a result of the complex treatment with Brovitacoccid, Rombendasol 2,5% and Tilozin 200 of the infected cattle by the parasite association Eimeria spp. S. papillosus, D. lanceolatum and E. granulosus larvae at 56 th day post-therapeutically the morpho-functional indexes re-establish in a rate of about 22,0%, while the treatment with Umbelicen, Brovitacoccid, Rombendasol 2,5% and Tilozin 200 contribute to the restoring of the mentioned indexes in proportion of about 55,5%. The use of Umbelicen within the antiparasite treatment schemes reduces the adverse effects of the parasitic and iatrogenic factors, due to the anti-inflammatory, regenerative, immunomodulatory and improvement properties of the protein metabolism.
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