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Clinical Picture Correlation of Psoriatic Arthritis with Immune-Monogenetic Determinants (HLA Class)


Author: Russu Eugeniu
Degree:doctor of medicine
Speciality: 14.00.06 - Cardiology and Rheumatology
Year:2010
Scientific adviser: Constantin Babiuc
doctor, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific consultant: Gheorghe Muşet
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution: State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific council: D 51-14.00.06
Public Medico-Sanitary Institution Moldavian Institute of Cardiology

Status

The thesis was presented on the 21 April, 2010
Approved by NCAA on the 3 June, 2010

Abstract

Adobe PDF document1.22 Mb / in romanian

Keywords

psoriatic arthritis, immune-genetic status, HLA, T- and B-lymphocytes, T-helper, T-suppressor, IgA, IgM, IgG, CIC

Summary

It consists 137 pages of main text with comprises: introduction and 6 chapters, bibliography (185 sources), 7 appendices, 32 tables and 46 figures. The derived results have been presented in 14 scientific studies: 5 articles. Domain of research: Rheumatology

The research objective consisted in study of correlation features of clinical course of patients with psoriatic arthritis, of immune and immune-monogenetic status in various clinical forms of arthritis, and the determination of importance of different variants of HLA antigens.

Methodology of the research: In the study frame there have been involved the fallowing research methods: history, physical examination, laboratory testing, special investigations, and statistical methods.

Scientific novelty and originality of this work consisted in revelation of clinical peculiarities of arthritis course in different forms, with deep associative analysis of immune-pathological and immune-genetic changes inherent in each clinical variant of psoriatic arthritis course. Pronounced immunosuppressive condition has been discovered along with amount decrease of T-lymphocytes CD3, CD8, CD4, B-lymphocytes and CD4/CD8 factor, as well as content malfunction of IgA, IgG, IgM and CIC. HLA-B27/B8, -B27/B62, -B27/B11 antigens have been declared unfavorable and extra-articulate display risk enhancing, while HLA-A2/A3, A2/A5, -A2/A8, -A3/A8 and -B27/A3 antigens were considered as favorable for a clinical course.

Theoretical value and of the work consists in detailed description of clinical features of psoriatic arthritis itself and its course variants, which will make possible to speed up timely diagnosis statement and allow giving the right characterization to immune-pathological changes. Practical value – there have been revealed some HLA antigens for psoriatic arthritis for proper treatment and patient’s life quality improvement.

The results have been introduced at: rheumatology department of Republican Clinical Hospital; rheumatology department of “Sfântă