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Clinical and social impact of psoriatic arthritis

Author: Rotaru Tatiana
Degree:doctor of medicine
Speciality: 14.00.06 - Cardiology and Reumatology
Scientific adviser: Minodora Mazur
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific consultant: Mihai Popovici
doctor habilitat, professor, Medical-Sanitary Public Institution Institute of Cardiology
Institution: Medical-Sanitary Public Institution Institute of Cardiology


The thesis was presented on the 16 March, 2023 at the meeting of the Scientific Council and now it is under consideration of the National Council.


Adobe PDF document0.68 Mb / in romanian


CZU 616.72-002:616.517+316.6 (043.2)

Adobe PDF document 2.72 Mb / in romanian
183 pages


psoriatic arthritis, clinical instruments, activity, DAPSA, PsAID, disability, WPAI, direct costs, indirect costs


Thesis structure: the thesis is presented on 183 electronic text pages, 120 basic text pages and includes: introduction, 4 chapters, conclusions and practical recommendations, bibliography with 172 literary sources. The thesis is illustrated with 20 tables, 28 figures, 18 annexes. The obtained results were published in 14 scientific works, 2 innovator certificates.

Purpose of the paper: was to study the areas of impact and important concepts for approaching psoriatic arthritis from the patient's perspective.

Research objectives: 1. To investigate the influence of demographic and socio-economic factors on patients with psoriatic arthritis and their role in the development of the disease. 2. Assessment of specific clinical tools for PsA and their clinical and diagnostic use. 3. Estimation of medication in terms of patient's perspective. 4. Determination the costs of psoriatic arthritis for the patients and predictive factors to reduce costs. 5. Development of an individualized approach model for patients with psoriatic arthritis, which will contribute to optimizing the management of patients with psoriatic arthritis.

Scientific novelty and originality: From the perspective of the cross-sectional study, conducted to assess areas of impact, a group of patients with confirmed PsA was evaluated. For the first time, WPAI, the direct and indirect costs for patients with PsA were calculated. The quality of the medical act was outlined.

The important scientific problem solved in the thesis consisted in the development of a personalized approach algorithm for the PsA patient, which contributed to the optimization of the curative behavior and allowed to reduce the impact of the disease on the psoriatic arthritis patient. Obtained results contribute to: the elaboration of a personalized approach algorithm of the patient with PsA, the optimization of their behavior and the diminution of the impact of the disease.

Theoretical significance of the work: The study argued the usefulness and informativeness of contemporary tools for assessing the patient with PsA and established the factors that influence the burden of disease.

Application value: The results of the multilateral study, using clinical, paraclinical, imaging parameters and clinical tools, contributed to the identification of factors influencing psoriatic arthritis.