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Clinical and evolutive particularities of psoriatic arthritis and its influence on quality of life


Author: Bodrug Inga
Degree:doctor of medicine
Speciality: 14.00.06 - Cardiology and Rheumatology
Year:2010
Scientific adviser: Minodora Mazur
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution:
Scientific council:

Status

The thesis was presented on the 25 August, 2010
Approved by NCAA on the 6 October, 2010

Abstract

Adobe PDF document0.81 Mb / in romanian

Keywords

psoriatic arthritis, tools for disease assessment, enthesitis, radiological evaluation, response criteria, quality of life

Summary

The thesis contains introduction, 4 chapters, conclusions and practical recommendations, it is presented on 125 pages of typed text, illustrated with 40 tables and 16 diagrams, reference list quotes 195 sources and 11 appendices. The results of the thesis were published in 9 scientific works.

Domain of research: Rheumatology

Aim of study: Research of the peculiarities of articular system affection in psoriatic arthritis as well as the evaluation of disease modifying anti-rheumatic drugs impact on quality of life.

Study objectives include: analysis of clinical features in psoriatic arthritis’ patients, enthesitis evaluation in different stages of the disease, radiological changes determination with special X ray score, quality of life evaluation with special regard to osteoarticular system function and the severity of skin lesions and determination of the disease modifying antirheumatic drug’s efficacy through treatment response criteria.

Study novelty and originality: There was performed a complex evaluation of musculoskeletal and skin manifestations of psoriatic arthritis, while using the modern diagnostic instruments for its early manifestations diagnosis, that being done for the first time. As well the study confirmed the influence of disease modifying anti-rheumatic drugs on patients’ quality of life reduction.

Theoretical value: The results of the research has proved utility and informational value of the modern methods of psoriatic arthritis evaluation: Visual Analogical Scale – VAS, enthesitis assessment, ACR count (swollen / tender joints), axial disease activity, imaging scoring methods, imaging quantification scores and questionnaires for quality of life assessment. Practical value: There was elaborated a complex assessment model for patients with peripheral/axial psoriatic arthritis, enthesial affection and skin lesions.

Practical implementation: The results of the study have been implemented in educational process at the Internal Medicine Nr. 3. Department of the State University of Medicine and Pharmacy “N.Testemitanu”, and in practical work of the 4th Department of the Institute of Cardiology.