StatusThe thesis was presented on the 1 December, 2010
Approved by NCAA on the 24 February, 2011
Abstract– 0.35 Mb / in romanian
Structure of the research work: introduction, four chapters, conclusions, bibliography from 211 titles, 5 annexes, 119 pages containing the basic text, 25 images, 12 tables, 8 formulas. The results are published in 11 scientific works. A patent of invention was obtained.
Domain of study: dentistry, oro-maxillo-facial surgery.
Purpose of the research work: Improvement of the efficiency of the medical assistance rendered to the patients with postextractional dental hemorrhages by optimization of the prophylactic and therapeutic methods.
Objectives: To determine the time of the blood clot formation and to assess its quality in patients with a non-compromised haemostatic system; to evaluate the frequency and the etiological factors of postextractional dental hemorrhages; to estimate the peculiarities of the clinical picture of the postextractional hemorrhage depending on etiology; elaboration of the method which provides haemostasis by using human thrombin and aminocaproic acid of 5%; to analyze the efficiency of the local haemostatic treatment through application of sutures and human thrombin; to determine the optimum conditions for performing the tooth extraction in patients receiving antithrombotic medication without cancellation of these drugs; to carry out the algorithm of prophylaxis and treatment of the postextractional hemorrhages.
Scientific novelty and originality: The quality of the blood clot was studied in patients with a non-compromised haemostatic system as well as its peculiarities depending on the etiological factor of the hemorrhage. A new method of haemostasis in postextractional dental hemorrhages was elaborated.
Theoretical significance: Thrombin initiates thrombogenesis using fibrinogen of the adjacent tissues, contributing to the clot formation, thus the hemorrhage being stopped.
Applicational value of the research work: The results of the study have been used to elaborate the algorithm of prophylaxis and treatment of the postextractional dental hemorrhage.
Implementation of the scientific results: The results of the study have been implemented in the current clinical practice at the following chairs: Oro-maxillo-facial surgery; Orthopedic dentistry, Oro-maxillo-facial surgery and Oral Implantology of SUMPh “Nicolae Testemiţanu”. The results of the research study are widely used by medical practitioners of The Republican Centre of oro-maxillo-facial surgery from the Republic of Moldova.