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Postextractional dental hemorrhages


Author: Zănoagă Oleg
Degree:doctor of medicine
Speciality: 14.00.21 - Stomatology
Year:2011
Scientific adviser: Valentin Topalo
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific consultant: Ion Corcimaru
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution: State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific council: DH 50-14.00.21
State University of Medicine and Pharmacy "Nicolae Testemitanu"

Status

The thesis was presented on the 1 December, 2010
Approved by NCAA on the 24 February, 2011

Abstract

Adobe PDF document0.35 Mb / in romanian

Keywords

tooth extraction, postextractional dental hemorrhage, thrombin, haemostasis, blood clot

Summary

Structure of the research work: introduction, four chapters, conclusions, bibliography from 211 titles, 5 annexes, 119 pages containing the basic text, 25 images, 12 tables, 8 formulas. The results are published in 11 scientific works. A patent of invention was obtained.

Domain of study: dentistry, oro-maxillo-facial surgery.

Purpose of the research work: Improvement of the efficiency of the medical assistance rendered to the patients with postextractional dental hemorrhages by optimization of the prophylactic and therapeutic methods.

Objectives: To determine the time of the blood clot formation and to assess its quality in patients with a non-compromised haemostatic system; to evaluate the frequency and the etiological factors of postextractional dental hemorrhages; to estimate the peculiarities of the clinical picture of the postextractional hemorrhage depending on etiology; elaboration of the method which provides haemostasis by using human thrombin and aminocaproic acid of 5%; to analyze the efficiency of the local haemostatic treatment through application of sutures and human thrombin; to determine the optimum conditions for performing the tooth extraction in patients receiving antithrombotic medication without cancellation of these drugs; to carry out the algorithm of prophylaxis and treatment of the postextractional hemorrhages.

Scientific novelty and originality: The quality of the blood clot was studied in patients with a non-compromised haemostatic system as well as its peculiarities depending on the etiological factor of the hemorrhage. A new method of haemostasis in postextractional dental hemorrhages was elaborated.

Theoretical significance: Thrombin initiates thrombogenesis using fibrinogen of the adjacent tissues, contributing to the clot formation, thus the hemorrhage being stopped.

Applicational value of the research work: The results of the study have been used to elaborate the algorithm of prophylaxis and treatment of the postextractional dental hemorrhage.

Implementation of the scientific results: The results of the study have been implemented in the current clinical practice at the following chairs: Oro-maxillo-facial surgery; Orthopedic dentistry, Oro-maxillo-facial surgery and Oral Implantology of SUMPh “Nicolae Testemiţanu”. The results of the research study are widely used by medical practitioners of The Republican Centre of oro-maxillo-facial surgery from the Republic of Moldova.