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Loading reactivity of the heart and coronary system in experimental heart failure and the correcting effect of natural remedies

Author: Cobeţ Valeriu
Degree:doctor habilitat of medicine
Speciality: 14.00.06 - Cardiology and Reumatology
Scientific consultant: Mihai Popovici
doctor habilitat, professor, Medical-Sanitary Public Institution Institute of Cardiology
Institution: Medical-Sanitary Public Institution Institute of Cardiology
Scientific council: DH 51-14.00.06-27.03.08
Medical-Sanitary Public Institution Institute of Cardiology


The thesis was presented on the 25 February, 2011
Approved by NCAA on the 12 May, 2011


Adobe PDF document0.45 Mb / in romanian


isolated heart and vessel, volume and resistance loading, myocardium inotropism, endothelin-1 (ET-1) receptors blocking, coronary phenomenon of Gregg, apoptosis, natural remedies


The theses consists of 231 pages, contains introduction, 6 chapters, bibliography by 297 sources, 51 tables and 56 figures. The results are published in 117 scientific works.

Domain of research: cardiology

Aim of research: Evaluation of the loading reactivity peculiarities of heart and coronary system in experimental heart failure (HF) as well as of the correcting effect of some natural remedies (taurine, vitamin E, magnesium and extract of Spiruline).

Objectives of research: Evaluation of the heart reactivity in volume and resistance efforts, in frequency-force relation, as well as of the myocardial inotropism on neuroendocrine factors action. Assessment of the apoptosis prevalence and of the collagen expression ratio. Estimation of the endothelium dependent and endothelium independent coronary reactivity. Functional assay of the natural remedies effect on the heart failure evolution.

Novelty and originality of research: Primary are proven evidences concerning interaction of heterometric and homeometric mechanisms in the heart adaptation on diverse effort tests as well as the coronary phenomenon Gregg features in heart failure.

Theoretical significance: Is based the pathogenic contribution of the myocardial isovolumetric relaxation and contraction in the pump function impairment as well as the compensatory role of the hyperpolarization mechanism in the coronary tone control, augmented by bradykinine receptor B1 ”up” expression. Is underlined the high incidence of the cardiac cell apoptosis in doxorubicin induced cardiomyopathy.

Applied value: Is emphasized the predictive role of the maximal myocardial contraction and relaxation velocity in the early diagnosis of heart failure. Are specified the options of the ET-1 receptor blockage dependently of the vascular endothelium functioning for a superior therapeutic effect obtainment in heart failure.

Practical implementation: the study results were proven as scientific point and have been implemented in the clinic of the Institute of Cardiology.