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CNAA / Theses / 2011 / July /

Particularities of locomotor impairment in patients with diabetes mellitus type 2”


Author: Chişlari Lia
Degree:doctor of medicine
Speciality: 14.00.06 - Cardiology and Rheumatology
Year:2011
Scientific adviser: Liliana Groppa
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific consultant: Zinaida Anestiadi
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution: Public Medico-Sanitary Institution Moldavian Institute of Cardiology
Scientific council: D 51-14.00.06
Public Medico-Sanitary Institution Moldavian Institute of Cardiology

Status

The thesis was presented on the 1 July, 2011
Approved by NCAA on the 5 October, 2011

Abstract

Adobe PDF document0.27 Mb / in romanian

Keywords

diabetic osteoartropathia, type 2 diabetes, impaired periarticular, quality of life, SF-36, joint inflammation, dystrophic osteoarticular degenerative process.

Summary

Thesis has done by Lia Chişlari “Particularities of locomotor impairment in patients with diabetes mellitus type 2” request scientific degree Doctor of Medicine, Republic of Moldova, or. Chisinau, 2011. Contains 156 pages of the basic text, and consisted of an introduction, six chapters, bibliography ( 134 sources), 9 annexes, 17 tables, 56 figures. The results are published in 16 scientific journals, 13 articles.

Field of study: rheumatology.

The purpose of the study was to evaluate the clinical and laboratory features of osteoarticular alterations in patients with type 2 diabetes to assess the presence, type and damage joints and periarticular expression with developing a recommendation for early diagnosis and initiation of prophylactic measures. Study objectives were frequently encountered in the assessment of joints in patients with type 2 diabetes through correlative methodology; periarticular expression of determination clinical joints damage, analysis of inflammatory joint event with appearances pathological laboratory data, assessment of bone metabolism disturbances and quality of life of patients with type 2 diabetes.

Research Methodology: The study was implemented in the following research methods: survey, examining the patient, laboratory investigations, special investigations (the study of pathogenetic status), statistical methods.

Novelty and originality was to reveal the clinical features of diabetic osteoartropathia, which were characterized by an early onset of joint damage in patients with type 2 diabetes, with a negative constant progression of joint disease, wide variety of clinical manifestations and joint periarticular ligament and aponeurozelor impaired. Quality of life in patients with type 2 diabetes associated with diabetic osteoartropatie presented that natural health concepts of SF-36 are directly modified by diabetic osteoartropatia, and the mental are mainly influenced by diabetes.

The theoretical significance of the study was to reveal the clinical, laboratory and evolutionary of diabetes osteoartropathia, including through the analysis of the impact on quality of life. The practical value is the revealing of the clinical and laboratory features of diabetic osteoartropathia that will contribute to accurate and early diagnosis of disease, allowing an effective therapeutic approach and improve quality of life.

The findings were implemented in the rheumatology department PMSI MCH “Holy Trinity”, are exposed in training for doctors at the Department of Internal Medicine No. 1 FR and SC.