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Involvement of respiratory system in systemic lupus erythematosus

Author: Cebanu Mariana
Degree:doctor of medicine
Speciality: 14.00.06 - Cardiology and Reumatology
Scientific adviser: Minodora Mazur
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova


The thesis was presented on the 5 October, 2015
Approved by NCAA on the 19 November, 2015


Adobe PDF document0.76 Mb / in romanian


CZU 616-002.524+616.2

Adobe PDF document 3.03 Mb / in romanian
180 pages


systemic lupus erythematosus, respiratory system, disease assessment tools, pulmonary function tests, risk factors, quality of lif


The work is exposed on 180 pages of typed text and is divided into: introduction, 5 chapters, conclusions and practical recommendations. Bibliographic index cites 250 literary sources. The thesis is illustrated with 33 tables, 26 figures and 12 appendices. The results of the thesis were published in 30 cientific works, 3 innovator certificates.

Domain of research: rheumatology.

Aim of the study: to study the types of respiratory involvement in SLE overlaping with disease activity, duration and the impact on the level of patient satisfaction.

Study objectives: to highlight the types of respiratory system pathology in patients with SLE; to establish the correlation with clinical symptoms, imaging and immunological markers; to assess the significance of the functional respiratory tests and high resolution computed tomography as methods for early diagnosis of lung pathology; to assess the impact on the level of satisfaction and general psychological well-being, to identify the predictive factors of lung involvement in SLE.

Methodology of scientific research: is based on questionnaires, clinical and laboratory examination, special studies (imaging, pulmonary function tests and instruments for disease activity measures and organ damage) and statistical analysis methods.

Scientific novelty and originality: in the descriptive study were investigated as a whole the clinical and laboratory particuliarities of patients with SLE and lung involvement. For the first time were applied the new SLICC (2012) classification criteria for lupus. It was established the impact of disease on quality of life of patients with lung injury by indices of satisfaction and general well-being. A new research direction was to determine the predictive factors for lung involvement in SLE.

The scientific problem solved in the thesis: The study identified the types of pulmonary impairment and their correlation with clinical and laboratory characteristics and estimated disease impact on satisfaction and general well being of patients with development of an holistic approach to SLE patients with pulmonary involvement. Theoretical importance of the research: the study issued an integral prototype of assessment of patients with SLE and lung impairement, highlighting the types of lesions, assessment tools and assessment of quality of life.

Applicative value of the work: the results of the study have argued the utility and informativity of SLE assessment instruments and modern methods of diagnosis of lung pathology.

Practical implementation: The research results were used in the training process at the Department of Internal Medicine and in practical work of IV Section of the Cardiology Institute.