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Evaluation of simvastatin on oxidative stress in patients undergoing coronary angioplasty


Author: Dumanschi Carolina
Degree:doctor of medicine
Speciality: 14.00.06 - Cardiology and Reumatology
Year:2015
Scientific adviser: Victoria Ivanov
doctor habilitat, professor, Medical-Sanitary Public Institution Institute of Cardiology
Scientific consultant: Ion Popovici
doctor habilitat, professor
Institution: Medical-Sanitary Public Institution Institute of Cardiology

Status

The thesis was presented on the 16 October, 2015
Approved by NCAA on the 22 December, 2015

Abstract

Adobe PDF document – 0.73 Mb / in romanian

Thesis

CZU 616.132.2-089.844+615.272.4

Adobe PDF document 3.05 Mb / in romanian
173 pages

Keywords

statins, percutaneous coronary intervention, restenosis, oxidative stress, major cardiovascular events.

Summary

The thesis is exposed on 173 pages and consists of introduction, 4 chapters, conclusions, practical recommendations, bibliography from 195 sources. Illustrative material includes 42 tables and 24 figures. The obtained results are published in 14 scientific works.

Domain of research: cardiology.

Goal: Evaluation of the effectiveness of statins in the prevention and treatment of coronary alterations after interventional procedures with stent implantation.

Objectives of research: Determination of the altered myocardial markers after coronary angioplasty with stent implantation. Dinamics of markers of oxidative stress, endothelial dysfunction and inflammation in the immediate and late period after coronary angioplasty (PCI). Assessment of the effects of different doses and the application ways of statins and the influence of the type of stent used (metal or coated) on appointed markers. Evaluation of major cardiovascular events in the immediate and late period after coronary angioplasty.

Novelty and originality of research: The study brought further evidence on pathogenetic mechanisms targeting vascular alterations caused by coronary angioplasty, the role of oxidative stress and inflammation in the evolution of this process. In this study, for the first time in our country, attempts of myocardial and vascular periprocedural protection with various schemes and doses of statins administration have been made, including locally (stent coated with statins).

Scientific problem solved: Coronary angioplasty is accompanied by an increase of parameters of oxidative stress, activation of inflammation and endothelial dysfunction.

Theoretical value: Evidence of the positive role of statins on oxidative stress, inflammation and endothelial dysfunction parameters, and on major cardiovascular events have been obtained.

Applied value: High doses, 80 mg given 12 hours before the angioplasty, as well as local action of simvastatin are more effective than low doses in reducing oxidative stress and inflammation development.

Practical implementation: The study results were estimated as scientific valuable and have been implemented in current curative activity of the Institute of the Cardiology.