The design and synthesis of biologically active 3d metal coordination compounds of 4-allylchalcogensemicarbazones and their derivatives
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StatusThe thesis was presented on the 12 April, 2017Approved by NCAA on the 31 May, 2017 Abstract – 0.65 Mb / in romanian – 0.60 Mb / in russianThesisCZU 54-386:546.47’56’72’73’74’:547.497.1:615.28
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Keywords
coordination compounds, 3d metals, 4-allylchalcogensemicarbazones, 4-allyl-S-methylisothiosemicarbazones, antiproliferative activity, antimicrobial activity, antifungal activitySummary
The thesis consists of introduction, four chapters, general conclusions and recommendations, 148 references, 5 annexes, 120 pages, 53 figures, 20 schemes, 31 tables. The results are published in 17 scientific publications (4 articles, 12 theses at conferences, 1 patent).
Field of study: Nature Sciences
The aim and the objectives of the thesis. The aim of this thesis consists in determination of the influence on the biological activity of different substituents in the first position of 4-allylthiosemicarbazide, alkylation of sulphur atom, and substitution of sulphur atom by selenium atom; determination of the influence of the nature of central atom, nature of ligands, introduction of amines in the inner sphere on composition, structure, physic-chemical and biological properties of the coordination compounds with these ligands; finding of new substances with selective antiproliferative activity against cancer cells and low toxicity. For achievement of these aims, the following objectives were set: synthesis of different 4-allylchalcogensemicarbazones; alkylation of sulphur atom; synthesis of complexes of some 3d metals with these ligands; introduction of amines in the inner sphere of complexes; determination of composition, structure and biological activity of the synthesized substances.
Novelty and relevance of the study consists in the synthesis of 74 new organic and coordination compounds, determination of the effect of substituents in the first position of thiosemicarbazides, alkylation of sulphur atom and substitution of sulphur by selenium atom, introduction of amines in the inner sphere on the properties of biometal coordination compounds.
Scientific problem solved in this thesis: new inhibitors of cancer cells proliferation with high selective activity and low toxicity were synthesized.
The theoretical importance and potential application value of the work. The list of biologically active organic and coordination compounds was enlarged. The influence of different fragments in their composition on the antimicrobial and antitumor properties was determined.
Implementation of scientific results.It was demonstrated that the synthesized substances manifest selective antiproliferative activity towards cancer cells, antimicrobial and antifungal activities and low cytostatic activity against normal cells.
Oficial Reviewers
- Diana Dragancea
doctor, associate professor (docent) - Cecal Alexandru
doctor în ştiinţe chimice, professor Emeritus, Universitatea Alexandu Ioan Cuza din Iaşi, România
Council's Members
- Vasile Guţanu, president
doctor habilitat, professor, Moldova State University - Maria Bîrcă, secretary
doctor, associate professor (docent) - Valeriu Rudic, member
doctor habilitat, professor, Institute of Microbiology and Biotechnology of the ASM - Ion Bulimestru, member
doctor, associate professor (docent) - Aliona Cotovaia , member
doctor, associate professor (docent) - Ion Bulhac, member
doctor habilitat, associate professor (docent), Institute of Chemistry of the ASM
Theses
