StatusThe thesis was presented on the 14 June, 2017
Approved by NCAA on the 11 May, 2018
Abstract– 1.22 Mb / in romanian
14.08 Mb /
Lupasco Iulianna. "Chronic Viral Hepatitis B And C In Adults." The thesis for the degree of Doctor Habilitatus of Medical Sciences, Chisinau, 2017.
The volume and structure of the thesis: the introduction, 6 chapters, the main conclusions and recommendations, bibliography of 223 sources, the main body of the text 203 p., 15 tables, 106 figures, 5 appendix. The results were published in 200 scientific papers. Keywords: chronic diffuse liver disease, viral hepatitis B and C, risk factors, hormones, hepatic laboratory syndromes, antiviral therapy. Field of the study: internal medicine, hepatology.
Aim: to study the frequency of chronic viral hepatitis B and C among other forms of CDLD in the course of profilaxy screening of healthy adult population of Republic of Moldova with identification of risk factors, evaluation of metabolic-hormonal profile, elaboration of diagnostic criteria of chronic hepatitis B and C difference from other forms of CDLD, in dependence on the variant and activity of the disease; optimization of monitoring enhancement of patients with CH C who receive AVT.
Objectives: Evaluation of the frequency of chronic hepatitis B and C in adults among the other forms of CDLD during profilaxy screening of population of Republic of Moldova, evaluating risk assessment of their occurrence, metabolic and hormonal characteristics with development of criteria for differential diagnosis of chronic viral hepatitis B and C from other CDLD. Sincronous evaluation of liver function tests, hipofiz-adrenal as well as thyroid and pancreatic hormonal profile, and oxidative stress markers (in dynamics of glucose-euphyllin test) in CH B and C in function of form and activity of the disease. Treatment efficacy studying and monitoring refinement of patients with chronic viral hepatitis C. Scientific novelty: for the first time in Moldova was revealed the prevalence of CH and other forms of CDLD, among group of people, considering themselves healthy; were assessed risk factors for their occurrence, are designed metabolic and hormonal criteria for the differential diagnosis of CH from other forms of CDLD. For the first time was used author’s euphyllin-glucose test for early diagnosis of metabolic, hormonal disorders in different forms of chronic hepatitis B and C in adults. It was elaborated the complex theory of CH B and C pathogenesis with disclosure of the role of hormones and oxidative stress in their development. It was optimized the monitoring of CH HCV patients receiving antiviral therapy. New directions of research: scientific substantiation of new platform in the field of hepatology: hormonal and metabolic relationships between main liver syndromes, reflecting deep hepatic and endocrine changes in chronic viral hepatitis B and C and other forms of CDLD in adults, development of fundamentally new methods of early recognizers and differential diagnosis of metabolic-hormonal disorders in CH B and C in adults, depending on the disease variant and activity. It was mproved monitoring of HCV patients receiving antiviral therapy. Implementation of scientific results: in the educational process (chapters in the guide, the monograph) in the practice of the medical institutions of RM (examination and treatment standards, national protocols).Theoretical and practical significance: It was recommended a new original method for diagnosis of liver function and hormonal status with CH B and CH C in adults via euphyllin-glucose test. There were developed the metabolic and hormonal criteria for the diagnosis and differential diagnosis of CH B and CH C in adults. It was optimized the monitoring of adult patients with CH C under antiviral therapy includimg an assessment of humoral immunity, thyroid function and POL/SAO system.