StatusThe thesis was presented on the 29 June, 2018
Approved by NCAA on the 23 November, 2018
Abstract– 0.69 Mb / in romanian
5.76 Mb /
The research domain:rheumatology, endocrinology.
The purpose of the study: determining the clinical and paraclinical particularities of musculoskeletal disorders in patients with hypothyroidism, elaboration of an early diagnostic algorithm, assessing of the quality of life and risk factors.
The research objectives: to find the incidence and features of the locomotor system in patients with primary hypothyroidism by determining the clinical pathological appearance, as well as, laboratory and instrumental results; to identify the early factors; to assess the impact of musculoskeletal impairment on quality of life in patients with primary hypothyroidism; to develop an early diagnostic algorithm.
Novelty and scientific originality.This paper describes the complex clinical and paraclinical of primary hypothyroidism associated with musculoskeletal disorders. It has described the spectrum of rheumatic involvement, risk factors, quality of life in patients with musculoskeletal disorders in primary hypothyroidism.
The scientific problem solved in the research. The types of locomotor system involvement in patients with primary hypothyroidism were identified that will contribute to the complex knowledge of this phenomenon, argued clinical and paraclinical signs in the early detection in order to optimize the behavior of these patients, ascertained the impact of locomotor impairment on quality of life in patients with primary hypothyroidism, assessed the risk factors in the development of rheumatic affections in hypothyroidism, elaboration of the early diagnosis algorithm for the locomotor system in patients with hypothyroidism, for subsequent use in clinical practice.
Theoretical significance of the thesis:The results of the study describe the peculiarities of the musculoskeletal impairment, the risk factors, and the quality of life of the patients suffering from musculoskeletal disorders in primary hypothyroidism.
The applied value of the thesis: the results of the current study will help to update clinical and paraclinical recommendations and optimize early diagnosis and selective treatment in patients with primary hypothyroidism associated with locomotor system disorders.
Practical implementation: The results of the study were applied in the teaching process within the curative activity of the Endocrinology and Arthrology Department of the Republican Clinical Hospital „Timofei Mosneaga”, and within the Chair of Endocrinology, as well as the Department of Internal Medicine, Chair of Rheumatology and Nephrology of „Nicolae Testemitanu” State University of Medicine and Pharmacy.