StatusThe thesis was presented on the 18 January, 2019 at the meeting of the Scientific Council and now it is under consideration of the National Council.
Abstract– 2.57 Mb / in romanian
10.18 Mb /
Thesis structure: Introduction, 5 chapters, general conclusions, recommendations, bibliography of 280 titles, 133 pages of main text, 57 figures, 70 tables, 11 annexes. Obtained results are published in 51 scientific papers, including one monograph.
Field of study: Pathology. Purpose of study: Evaluation of molecular profile of ductal and lobular invasive mammary carcinomas in comparison with ipsilateral lymph node metastases, as well evaluation of molecular subtypes’ stability during metastatic process.
Objectives: Tumor’s molecular phenotype assessment in relation to histological grade and type, lymph nodes involvement, as well evaluation of ER, PR, AR, HER2, CK5, EGFR, p53, BCL2 and E-cadherin stability during metastatic development of breast carcinoma.
Scientific innovation: For the first time was demonstrated the instability of ER, PR, AR, HER2, CK5, EGFR, p53, BCL2 and E-cadherin markers during metastatic development of ductal type NOS and lobular invasive carcinomas. We set it up for the first time that lymph node metastasis has a particular immunohistochemical phenotype, distinct from primary tumor, which arguments the revaluation necessity of modern concepts of treatment.
Theoretical significance and applied value of the work: The results of present work support the necessity of simultaneous imunohistochemical examination of primary tumor and metastasis, in reason of a personalized diagnostic and treatment evaluation. Implementation of scientific results: The obtained results were approved to have a scientific and practical value for histological, pathological, oncological departments’ and laboratories’ activity.