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The molecular profile of invasive breast carcinomas versus correspondent lymph node


Author: Fulga Veaceslav
Degree:doctor habilitat of medicine
Speciality: 14.00.15 - Pathological Anatomy
Year:2019
Scientific consultants: Lilian Şaptefraţi
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Raica Marius
doctor, profesor universitar, UMF „Victor Babeș”, Timișoara, România
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 18 January, 2019
Approved by NCAA on the 15 March, 2019

Abstract

Adobe PDF document – 2.57 Mb / in romanian

Thesis

CZU 618.19-006.6-033.2(043.2)

Adobe PDF document 10.18 Mb / in romanian
261 pages

Keywords

mammary carcinoma, hormonal markers, HER2, CK5, EGFR, p53, BCL2, Ecadherin, molecular subtypes, lymph node metastases

Summary

Thesis structure: Introduction, 5 chapters, general conclusions, recommendations, bibliography of 280 titles, 133 pages of main text, 57 figures, 70 tables, 11 annexes. Obtained results are published in 51 scientific papers, including one monograph.

Field of study: Pathology. Purpose of study: Evaluation of molecular profile of ductal and lobular invasive mammary carcinomas in comparison with ipsilateral lymph node metastases, as well evaluation of molecular subtypes’ stability during metastatic process.

Objectives: Tumor’s molecular phenotype assessment in relation to histological grade and type, lymph nodes involvement, as well evaluation of ER, PR, AR, HER2, CK5, EGFR, p53, BCL2 and E-cadherin stability during metastatic development of breast carcinoma.

Scientific innovation: For the first time was demonstrated the instability of ER, PR, AR, HER2, CK5, EGFR, p53, BCL2 and E-cadherin markers during metastatic development of ductal type NOS and lobular invasive carcinomas. We set it up for the first time that lymph node metastasis has a particular immunohistochemical phenotype, distinct from primary tumor, which arguments the revaluation necessity of modern concepts of treatment.

Theoretical significance and applied value of the work: The results of present work support the necessity of simultaneous imunohistochemical examination of primary tumor and metastasis, in reason of a personalized diagnostic and treatment evaluation. Implementation of scientific results: The obtained results were approved to have a scientific and practical value for histological, pathological, oncological departments’ and laboratories’ activity.