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CNAA / Theses / 2019 / June /

Clinical and molecular genetic peculiarities of symptomatic epilepsy due to neurocysticercosis


Author: Gorincioi Nadejda
Degree:doctor of medicine
Speciality: 14.00.13 - Neurology
Year:2019
Scientific adviser: Stanislav Groppa
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Public Medical Sanitary Intitution Scientific Research Institute of Mother and Child Health Care

Status

The thesis was presented on the 7 June, 2019
Approved by NCAA on the 9 July, 2019

Abstract

Adobe PDF document – 0.92 Mb / in romanian

Thesis

CZU 616.853:616.993-056

Adobe PDF document 4.84 Mb / in romanian
180 pages

Keywords

neurocysticercosis, epilepsy, calcified cysticerci, electroencephalography, human leukocyte antigen system of histocompatibility, antihelmintic treatment

Summary

Structure of the thesis: The thesis is exposed on 180 pages of printed text and consists of introduction, four chapters, conclusions and recommendations, summary in Romanian, Rus-sian and English, bibliography with 200 references, 76 figures, 13 tables and 22 annexes, 151 pages of basic text. The results were published in 16 scientific papers in national and international journals.

Field of study: Neurology, Infectious Diseases, Medical Genetics.

The goal: To study the clinical, immunological, molecular-genetic features of the epilepsy due to neurocysticercosis in order to determine the clinical polymorphism and the role of histo-compatibility system in the assessment of the patients with hereditary predisposition to neuro-cysticercosis.

Objectives: study of clinical and molecular-genetic parameters in the patients with neuro-cysticercosis and with epilepsy due to neurocysticercosis according to international criteria; de-termination of the structural peculiarities of the patients with neurocysticercosis with and without seizures via neuroimaging; semiology assessment of seizures depending on localisation, size, number and viability of the larvae; the analysis of clinical, imaging and neurophysiological corre-lations in patients with epilepsy and neurocysticercosis; determination of the role of the human histocompatibility system by assessing the hereditary predisposition to neurocysticercosis.

Scientific novelty: The thesis presents a complex and interdisciplinary study of the epi-lepsy in the context of neurocysticercosis, which helped to identify the clinical features and, in particular, the molecular-genetic aspects of the epilepsy due to neurocysticercosis in Modavian patients, to establish the role of the histocompatibility system in the occurance and the evolution of severe forms of neurocysticercosis. Because of the received data and the proposed recomandations based on the research, this scientific work approached an essentially new and contemporary subject.

Problem solved in the thesis: is the determination of the clinical polymorphism correlat-ed with the neuroimaging, neurophysiological and imunnogenetic peculiarities of epilepsy due to neurocysticercosis; the identification of haplotypes of the histocompatibility system predisposing to occurance and evolution of severe forms of neurocysticercosis and epilepsy, with further es-tablishment of individualized treatment plans.

Theoretical significance of the study: Finding the correlation between clinical and para-clinical data (neuroimaging, neurophysiological, immunological and molecular genetic) in order to establish a prompt diagnosis and to individualize the treatment for the patients with neurocysti-cercosis.

Practical value of the work: was to provide proofes, evidences and scientific materials necessary for establishing the diagnosis and therapeutic management of patients with neurocysti-cercosis and epilepsy.

Implementation of scientific results: algorithms for diagnosis and adjustement of indi-vidual treatment schedules for the patients with epilepsy due to neurocysticercosis were devel-oped