Attestation committee
Accreditation committee
Expert committee
Dispositions, instructions
Normative acts
Nomenclature
Institutions
Scientific councils
Seminars
Theses
Scientific advisers
Scientists
Doctoral students
Postdoctoral students
CNAA logo

 română | русский | english


Exocrine pancreatic function in type 1 diabetes mellitus patients


Author: Porcereanu Natalia
Degree:doctor of medicine
Speciality: 14.00.05 - Internal Diseases (with specification: Pulmonology, Gastroenterology, Hepatology, Nephrology, Functional Diagnostics and Endoscopy)
Year:2019
Scientific adviser: Eugen Tcaciuc
doctor habilitat, associate professor (docent), Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 23 December, 2019 at the meeting of the Scientific Council and now it is under consideration of the National Council.

Abstract

Adobe PDF document0.48 Mb / in romanian

Thesis

CZU 616.379-008.64+616.37-008.64

Adobe PDF document 12.01 Mb / in romanian
165 pages


Keywords

type 1 diabetes mellitus, diabetic autonomic neuropathy, exocrine pancreatic insufficiency, pancreatic fecal elastase-1

Summary

Structure of the thesis: introduction, 4 chapters, conclusions, bibliography (257 sources). The thesisi consists of 153 text pages (130 basic text pages) and is illustrated with 13 figures, 28 tables. The results have been published in 11 scientific papers.

Field of the study:internal medicine, endocrinology, gastroenterology.

Aim of the study: Evaluation of clinical and laboratory particularities in type 1 diabetes mellitus patients with pancreatic exocrine insufficiency and elaboration of the recommendations for optimizing the therapeutic approach.

Objectives: Evaluation of the exocrine pancreatic function in type 1 diabetes mellitus patients. Evaluation of the nutritional status and biochemical profile of patients with type 1 diabetes and exocrine pancreatic insufficiency. Establishing associations between diabetic microvascular complications, between glycemic control and exocrine pancreatic insufficiency. Elaboration of recommendations for the early detection of exocrine pancreatic insufficiency.

Scientific novelty and originality: The research has provided new data on the clinical relevance of exocrine pancreatic insufficiency in patients with type 1 diabetes.Scientific solved problem: Evaluation of exocrine pancreatic insufficiency in patients with type 1 DZ, elucidation of provocative factors and establishment of associations with nutritional imbalance and gastrointestinal symptoms, diabetic microvascular complications and signs of autonomic digestive neuropathy.

Theoretical significance: The results of our study argue that exocrine pancreatic insufficiency is a pathological condition with a high prevalence in type 1 diabetes mellitus patients and can be seen as a manifestation of diabetic complications. Impact of exocrine pancreatic insufficiency on the quality of life, nutritional status and prognosis of patients implies the necessity of a timely diagnosis of exocrine pancreatic insufficiency and optimal therapeutic measures. The applicative value of the thesis: Revealing patients with type 1 diabetes who are at a high risk of pancreatic exocrine insufficiency.

Implementation of the scientific results: The results of the study were implemented in the practical work of the specialists of the Endocrinology and Gastroenterology Departments of the Municipal Clinical Hospital ,,Sfanta Treime”, the Gastroenterology Department of the Republican Clinical Hospital ,,Timofei Mosneaga”.