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The impact of metabolic syndrome and its components on right chambers of the heart


Author: Sedaia Ecaterina
Degree:doctor of medicine
Speciality: 14.00.06 - Cardiology and Reumatology
Year:2021
Scientific adviser: Valeriu Revenco
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 11 February, 2021
Approved by NCAA on the 25 June, 2021

Abstract

Adobe PDF document – 1.00 Mb / in romanian
Adobe PDF document – 1.07 Mb / in english

Thesis

CZU 616.123:616-008.9 (043.2)

Adobe PDF document 6.27 Mb / in romanian
128 pages

Keywords

metabolic syndrome, myocardial performance index Tei, diastolic function, systolic function, right ventricle, right atrium, visceral obesity, ventricular remodeling, right ventricular hypertrophy, epicardial fat thickness

Summary

The thesis is presented on 128 pages of typed electronic text and includes: introduction, 4 chaptesrs, general conclusions and practical recommendations. Bibliographic index quotes 234 published articles. The thesis contains illustrative materials, represented in 37 tables and 15 figures. The results of the study are published in 33 scientific works.

Aim of the study: to evaluate the impact of metabolic syndrome and its components on right heart geometry and function.

Objectives: to evaluate structural remodeling of right heart chambers in patients with metabolic syndrome according to its components; to study the impact of the components of metabolic syndrome and sex on right heart mechanics; sonographic evaluation of the epicardial fat thickness in patients with metabolic syndrome and its relation to other sonographic and anthropometric parameters of visceral obesity; to evaluate the correlation of epicardial fat thickness, visceral obesity, insulin resistance and dysfunction and remodeling of right ventricle and atrium in metabolic syndrome.

The scientific novelty and originality: the novelty and originality of the study consist in focusing of the scientific work on the determination of specific components of metabolic syndrome and parameters of visceral obesity responsible for remodeling (morphological and functional) of right heart chambers with underlining of some specific features dependent on sex.

The important scientific problem solved in the thesis consists in the revealing of the main components of metabolic syndrome with important impact on right heart chambers according to sex and association of visceral obesity.

The theoretical importance: the research showed important correlations of the components of metabolic syndrome and the parameters of right heart remodeling, that represent independent factors of prognosis for patients with/without cardiovascular pathology.

The applicable value of the work: the research results showed the importance of measurement of right ventricular hypertrophy, systolic, diastolic and global function of right ventricle, especially in patients with metabolic syndrome. These parameters represent important prognostic factors. More of that, the study demonstrated the necessity and possibility of introduction in daily practice of new parameters for the quantification of visceral obesity, such as epicardial fat thickness, for the complete assessment of cardiometabolic risk in patients with metabolic syndrome.

Practical implementation: The research results were implemented in clinical practice of PMSI Institute of Cardiology and educational process at the Discipline of Cardiology, Department of Internal Medicine, “Nicolae Testemițanu” State University of Medicine and Pharmacy of the Republic of Moldova.