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CNAA / Theses / 2021 / May /

Improvement of diagnosis and pharmacotherapy of the ear disorders


Author: PARII Sergiu
Degree:doctor habilitat of medicine
Speciality: 14.00.04 - Otorhinolaryngology
Year:2021
Scientific advisers: Veaceslav Gonciar
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Ghenadie Curocichin
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 19 May, 2021
Approved by NCAA on the 4 October, 2021

Abstract

Adobe PDF document – 1.51 Mb / in romanian

Thesis

CZU 616.28-008.1-07-085.2(043.2)

Adobe PDF document 16.00 Mb / in romanian
305 pages

Keywords

auditory analyzer, otitis, sensorineural deafness, diagnosis, prognosis, pharmacotherapy, combined drugs, otoprotective preparations

Summary

„Improvement of diagnosis and pharmacotherapy of the ear disorders” PhD Thesis in Medical Sciences, Chisinau, 2021 Thesis structure: introduction, five chapters, conclusions and recommendations, 259 bi- bliographic sources, 11 annexes, 210 pages basic text, 47 figures and 79 tables. The obtained re- sults are published in 59 scientific papers including 4 patents. Key words: auditory analyzer, otitis, sensorineural deafness, diagnosis, prognosis, phar- macotherapy, combined drugs, otoprotective preparations. Field of study: 314.01 – Pharmacology and clinical pharmacology, 321.16 - ENT (otorhi- nolaryngology). Purpose of study: development and study of the therapeutic effect of combined optrotec- tant drugs, updating of molecular genetic and audiological diagnostics, as well as the establish- ment of prognostic factors for the effectiveness of hearing recovery in inflammatory diseases of the ear and sensorineural hearing loss (SNHL). Objectives: To propose new concepts of using combined drugs containing active substan- ces of synthetic and natural origin in the treatment of ear diseases, developing principles for pre- dicting of auditory effects and genetic diagnosis of nonsyndromic SNHL, improving the efficiency of pharmacotherapy of ear pathology. Scientific innovation. Evaluation of the pre-clinical efficacy of the pharmaceutical pro- ducts CAF-01, NH-01 and CB-12. There was obtained the new theoretical knowledge on audiolo- gical and molecular-genetic diagnosis, the prediction of efficacy of pharmacotherapy, the adverse effects of hearing aids. The fundamentally new results in science and practice consist in the development of comprehensive research on the basis of complex interdisciplinary research of medicinal products with active substances of synthetic and natural origin, as well as a study of pharmacological safety and otoprotective efficacy. Development of principles for predicting the parameters of speech audiometry, the effec- tiveness of pharmacotherapeutic treatment and hearing aids for hearing impaired patients. mpro- vement of molecular genetic diagnostics for stratification of patients with SNHL and prevention of the corresponding pathology. Theoretical significance and applied value of the work. Has been developed a theoreti- cal and practical basis for an interdisciplinary and systemic conceptual approach of preclinical and clinical studies on the development, pharmacological treatment of otitis media and SNHL. Implementation of scientific results. The results were implimented in the practical acti- vities of the departments and laboratories with the specifics of pharmacology, pharmacy, human genetics and the ENT clinic of the SUMFh N. Testemitanu (2 registration certificates, 7 acts of implementation of inventions, 5 acts of implenetation of innovations).