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Synthesis and study of polynuclear coordination compounds of s- and d-metals with salicylic acid and its derivatives


Author: Gorincioi Viorina
Degree:doctor of chemistry
Speciality: 02.00.01 - Inorganic chemistry
Year:2022
Scientific adviser: Constantin Turtă
doctor habilitat, professor, Institute of Chemistry of the ASM
Scientific consultant: Vasile Lozan
doctor habilitat, associate professor (docent)
Institution: Institute of Chemistry of the ASM

Status

The thesis was presented on the 9 November, 2022 at the meeting of the Scientific Council and now it is under consideration of the National Council.

Abstract

Adobe PDF document1.71 Mb / in romanian

Thesis

CZU 546.3-32.057:547.587.11(043.2)

Adobe PDF document 9.12 Mb / in romanian
217 pages


Keywords

oxo–carboxylates of Fe(III) and Cu(II), heteropolynuclear clusters, salicylic acid, 3d– metals, Mössbauer spectroscopy, nanoparticles (NP), biological activity

Summary

Thesis structure: The thesis was performed at the Institute of Chemistry, the Laboratory of Bioinorganic Chemistry and Nanocomposites. The dissertation is written in Romanian and comprises introduction, 4 chapters, general conclusions and recommendations, bibliography of 332 titles, 135 pages of basic text, 73 figures, 15 tables and 13 annexes. The obtained results were published in 45 scientific papers, including: 16 articles; 23 abstracts at сonferences; 6 patents.

The aim of the thesis: it was focused on the synthesis and study of polynuclear coordination compounds of iron(III) and some –s, –d metals with salicylic acid and its derivatives, possessing properties applicable in practice by various physico-chemical methods.

Research objectives: Development of synthetic strategies of new homo– and heteronuclear complexes of s–d, d–d type based on salicylic acid and its derivatives; synthesis of coordination compounds with biologically active potential; the use of new synthesized Fe(III) salicylates as precursors for the synthesis of iron oxides nanoparticles.

Scientific novelty and originality: synthesis of 22 new Fe(III) and Cu(II) complexes, obtaining 13 NP samples using as precursors homo– and heteronuclear iron complexes of salicylic acid. It has been shown that salicylic acid is a versatile acid due to the achievement of different modes of coordination in the obtained systems. The biologically-active properties of some synthesized heteronuclear compounds as well as some NPs were highlighted.

The results obtained that contribute to solving an important scientific problem: developed optimal procedures for the synthesis of homo– and heteronuclear Fe(III) and Cu(II) clusters were established, and favorable conditions for NP obtaining were identified using Fe(III) clusters as precursors, the study of the biological and anticorrosive activity of the compounds that allowed the identification of biostimulatory, antimycotic and anticorrosive activities with increased applicative potential.

Theoretical significance: homo– and heteronuclear clusters of iron(III) with Mg(II), Ca(II), Sr(II), Ba(II), Cr(III), Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and cooper(II) with Ca(II), Sr(II), Ba(II) were synthesised. The solid state cluster structure were established and the physico-chemical and biological properties of Fe(III), Cu(II) coordination compounds and Fe(III) oxide NP were determined.

Applicative value: consists in the use of developed methods for the synthesis of salicylates to obtain new complexes with predetermined properties; the obtained clusters show anticorrosive, antiproliferative and biostimulatory properties.

Implementation of scientific results: there were demonstrated activity of Fe(III) heterotrinuclear salicylates on catalase biosynthesis in Penicillium piceum F–648 A3 and Penicillium funiculosum CNMN FD strains; the inhibitory properties of compounds [Fe3O(SalH)7(H2O)2]∙2DMA∙CH3OH∙1,5THF∙2,6H2O and [CuBa(SalH)4(DMA)4(H2O)] at fungal proliferation of Cryptococcus Neoformans species, the anticorrosive properties of compound {[FeSr2(Sal)2(SalH)2NO3(DMA)4]}n; the biostimulatory activity of NP on micromycetes of the genera Aspergillus, Penicillium and Trichoderma.