Synthesis and study of polynuclear coordination compounds of s- and d-metals with salicylic acid and its derivatives
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StatusThe thesis was presented on the 9 November, 2022Approved by NCAA on the 21 December, 2022 Abstract – 1.71 Mb / in romanianThesisCZU 546.3-32.057:547.587.11(043.2)
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Keywords
oxo–carboxylates of Fe(III) and Cu(II), heteropolynuclear clusters, salicylic acid, 3d– metals, Mössbauer spectroscopy, nanoparticles (NP), biological activitySummary
Thesis structure: The thesis was performed at the Institute of Chemistry, the Laboratory of Bioinorganic Chemistry and Nanocomposites. The dissertation is written in Romanian and comprises introduction, 4 chapters, general conclusions and recommendations, bibliography of 332 titles, 135 pages of basic text, 73 figures, 15 tables and 13 annexes. The obtained results were published in 45 scientific papers, including: 16 articles; 23 abstracts at сonferences; 6 patents.
The aim of the thesis: it was focused on the synthesis and study of polynuclear coordination compounds of iron(III) and some –s, –d metals with salicylic acid and its derivatives, possessing properties applicable in practice by various physico-chemical methods.
Research objectives: Development of synthetic strategies of new homo– and heteronuclear complexes of s–d, d–d type based on salicylic acid and its derivatives; synthesis of coordination compounds with biologically active potential; the use of new synthesized Fe(III) salicylates as precursors for the synthesis of iron oxides nanoparticles.
Scientific novelty and originality: synthesis of 22 new Fe(III) and Cu(II) complexes, obtaining 13 NP samples using as precursors homo– and heteronuclear iron complexes of salicylic acid. It has been shown that salicylic acid is a versatile acid due to the achievement of different modes of coordination in the obtained systems. The biologically-active properties of some synthesized heteronuclear compounds as well as some NPs were highlighted.
The results obtained that contribute to solving an important scientific problem: developed optimal procedures for the synthesis of homo– and heteronuclear Fe(III) and Cu(II) clusters were established, and favorable conditions for NP obtaining were identified using Fe(III) clusters as precursors, the study of the biological and anticorrosive activity of the compounds that allowed the identification of biostimulatory, antimycotic and anticorrosive activities with increased applicative potential.
Theoretical significance: homo– and heteronuclear clusters of iron(III) with Mg(II), Ca(II), Sr(II), Ba(II), Cr(III), Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and cooper(II) with Ca(II), Sr(II), Ba(II) were synthesised. The solid state cluster structure were established and the physico-chemical and biological properties of Fe(III), Cu(II) coordination compounds and Fe(III) oxide NP were determined.
Applicative value: consists in the use of developed methods for the synthesis of salicylates to obtain new complexes with predetermined properties; the obtained clusters show anticorrosive, antiproliferative and biostimulatory properties.
Implementation of scientific results: there were demonstrated activity of Fe(III) heterotrinuclear salicylates on catalase biosynthesis in Penicillium piceum F–648 A3 and Penicillium funiculosum CNMN FD strains; the inhibitory properties of compounds [Fe3O(SalH)7(H2O)2]∙2DMA∙CH3OH∙1,5THF∙2,6H2O and [CuBa(SalH)4(DMA)4(H2O)] at fungal proliferation of Cryptococcus Neoformans species, the anticorrosive properties of compound {[FeSr2(Sal)2(SalH)2NO3(DMA)4]}n; the biostimulatory activity of NP on micromycetes of the genera Aspergillus, Penicillium and Trichoderma.
Oficial Reviewers
- Ion Bulimestru
doctor, associate professor (docent) - PUI Aurel
doctor în științe chimice, profesor universitar, Universitatea ”Alexandru Ioan Cuzaˮ din Iași, România
Council's Members
- Ion Bulhac, president
doctor habilitat, associate professor (docent), Institute of Chemistry of the ASM - Maria Cocu, secretary
doctor, associate professor (docent) - Aurelian Gulea, member
doctor habilitat, professor, Moldova State University - Maria Bîrcă, member
doctor, associate professor (docent) - Sergiu Şova, member
doctor, associate professor (docent) - Liliana Cepoi, member
doctor, associate professor (docent), Institute of Microbiology and Biotechnology of the ASM
Theses
