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Strengthening the health of the population with high metabolic risks

Author: Fedaș Vasile
Degree:doctor habilitat of medicine
Speciality: 14.00.07 - Hygiene
Scientific consultant: Ion Mereuţa
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Institute of Physiology and Sanacreatology of the ASM


The thesis was presented on the 12 January, 2023 at the meeting of the Scientific Council and now it is under consideration of the National Council.


Adobe PDF document1.34 Mb / in romanian
Adobe PDF document1.32 Mb / in romanian


CZU 614.2:616-008.9(478)(043.2)

Adobe PDF document 12.57 Mb / in romanian
292 pages


health, metabolic risks, metabolism, metabolic disorders, hypertension, type II diabetes, dyslipidaemia, obesity, chronic systemic inflammation, biotyped and personalised lifestyle


Thesis structure: introduction, six chapters, general conclusions and practical recommendations, bibliography of 466 titles, 16 appendices, 190 pages of basic text, 24 figures, 51 tables. The results are published in 38 scientific papers.

Aim: To study the complex of measures needed to strengthen the health of the population at increased metabolic risk by developing new prevention methods and novel therapeutic management approaches.

Research objectives: 1) Statistical-demographic analysis of the population with increased metabolic and circulatory risks during 2015-2020 (hypertension, type II diabetes mellitus, obesity and dyslipidemias. 2) To identify and highlight the role and impact of major risk factors in the occurrence of key metabolic and circulatory disorders on population health. 3) To evaluate preclinical diagnostic methods for metabolic and circulatory disorders in people with increased metabolic risks. 4) Scientific argumentation of novel approaches in the application of new methods of rehabilitation and recovery for health fortification. 5) Development of recommendations for health education and healthy lifestyle with biotyped and personalized functional nutrition for subjects with increased metabolic risks. 6) Development of new products with metabolic-protective effect and study of their curative-prophylactic properties.

Scientific novelty and originality: For the first time, the impact of essential metabolic risk factors in the population, including chronic systemic inflammation and the role of microbiota, is argued; the population with hypertension, type II diabetes, dyslipidemia and obesity is analysed statistically and demographically, analytically and discriminately; metabolic readaptation and rehabilitation is scientifically argued; new products with a metabolic-protective effect are developed; biotyped and personalised lifestyle recommendations in subjects with metabolic tuburification are developed.

The result obtained, which contributes to the solution of an important scientific problem, is the development of the concept of the impact of metabolic risk factors in the population, including chronic systemic inflammation, the criteria of early detection of metabolic distortion, the possibilities of metabolic readaptation and rehabilitation, the elimination of oxidative stress, the argumentation of the new vision of biotyped and personalized lifestyle with the aim of education and strengthening the health of the population.

The theoretical significance lies in the development of the concept of triggering metabolic derangements involving chronic systemic inflammation, decreasing oxidative stress by administering metabolic bioprotective products with biotyping and individualization of healthy lifestyle.

The application value of the work lies in the development of the preclinical diagnostic method of metabolic disorders and prebiotic correction of intestinal biota; in the application of healthful nutrition, biotyped and individualized lifestyle, through medical education of the population, maintaining and strengthening the health of the population with increased metabolic risks.

Implementation of scientific results: the results of the research were implemented in the research process of the Institute of Physiology and Sanocreatology, similar institutes in Romania, Ukraine, Russia, in the teaching process of the State University of Moldova, the State University of Medicine and Pharmacy "N. Testemitanu", University of Tiraspol, in CME programs in rehabilitation and rehabilitation, in the work of family doctors, specialists in public and private medical institutions, in rehabilitation, health education centers.