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Clinico-genetic implications at hypertensive children with metabolic disorders suffering from overweight and obesity


Author: Cojocari Svetlana
Degree:doctor of medicine
Speciality: 14.00.06 - Cardiology and Reumatology
Year:2016
Scientific adviser: Nelea Mătrăgună
doctor habilitat, associate professor (docent), Medical-Sanitary Public Institution Institute of Cardiology
Scientific consultant: Nicolae Barbacar
doctor habilitat, professor, Institute of Genetics, Physiology and Plant Protection of the ASM
Institution: Medical-Sanitary Public Institution Institute of Cardiology

Status

The thesis was presented on the 25 March, 2016
Approved by NCAA on the 3 June, 2016

Abstract

Adobe PDF document – 1.48 Mb / in romanian

Thesis

CZU 616.12-008.331.1-053.2+616-056.52-056.57-053.2

Adobe PDF document 5.32 Mb / in romanian
203 pages

Keywords

arterial hypertension, overweight, obesity, risk factors, genetic polymorphism, genotype, adipokines, cytokines, metabolic syndrome, children

Summary

Structure of the thesis: introduction, 5 chapters, discussions, general conclusions and recommendations, bibliography of 345 names, 150 pages of main text, 51 tables, 22 graphs. The results obtained are published in 34 scientific works.

The field of study: cardiology.

The aim and objectives of the work: evaluation of clinic-genetic particularities and hormonal metabolic disorders in hypertensive children with overweight or obesity. Estimation of the behavioral factors, prenatal and genetic risk factors through determination of the polymorphism of the genes RAS (ACE, AGTR1), NOS3 and the disorders it courses, identification of the relation between the carrying of the genetic polymorphism of the genes studied and the components of the metabolic syndrome (MS), adipokines and pro inflammatory markers.

Scientific novelty and originality: There was determined a number of risk factors including genetic factor influencing development of the arterial hypertension and MS in children. There were also investigated some adipokines/cytokines as biomarkers in early diagnostics of the diseases.

Scientific problem solved: determination of the great number of risk factors including genetic ones and diagnostic biomarkers in children with overweight/obesity in order to optimize risk stratification, timely treatment and early prophylaxis that will add to reducing the number of children with arterial hypertension and MS.

Theoretical value: the applied research program on arterial hypertension and MS taking into consideration genetic markers, subclinical inflammation, adipokines and uric acid added new scientific arguments and gave an opportunity to recommend clear principles of adequate measures for effective prophylaxis.

Applied value: practical use of IDF criteria in diagnosing MS in children with overweight and obesity joined with determination of plasma (leptin, adiponectinTNF-α, hs-PCR, uric acid) and molecular genetic markers will contribute to early diagnosing of MS and its components, improving cardiovascular and genetic risk assessment. Implementation of scientific results: the research was put into practice in the City Clinical Hospital "V. Ignatenco", Cardiology Department, the scientific research base of the Cardiology Institute and Republic Children’s Clinical Hospital ,"E. Cotsaga”, Endocrinology Department.