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Estimation of the impact of mononucleotide polymorphisms on anthropometric risk factors for cardiovascular risk and lipid spectrum in young people


Author: Gavriliuc Svetlana
Degree:doctor of medicine
Speciality: 14.00.06 - Cardiology and Reumatology
Year:2019
Scientific adviser: Valeriu Istrati
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific consultant: Ghenadie Curocichin
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 27 February, 2019
Approved by NCAA on the 19 April, 2019

Abstract

Adobe PDF document – 0.85 Mb / in romanian

Thesis

CZU 616.12-008.9-056.52-056.7(043.2)

Adobe PDF document 8.76 Mb / in romanian
118 pages

Keywords

cardiovascular risk factors, young people, anthropometric indices, obesity, dyslipidemia, prophylaxis, mononucleotide polymorphism, genotype

Summary

Structure of the thesis: introduction, 4 chapters, conclusions and recommendations, bibliography from 171 sources, 104 pages, 45 tables, 39 figures. The derived results have been published in 11 scientific papers.

Field of study: Cardiology.

Purpose: studying the contribution of mononucleotide polymorphisms to young people. The trheeseeaxrpcrhesosbijoenctiovfesa:ntShtruodpyoimngettrhice aspnrdealdipoidf acnatrhdrioopvoamsceutlraicr rriisskk ffaaccttoorrss foinr cardiovascular risk; researching the spread and intensity of cardiovascular risk biochemical factors; detecting 9 mononucleotide polymorphisms; the statistical estimation of the association between the polymorphisms determined with the phenotypic manifestations studied.

The novelty and the scientific originality. Original data on the rate of obesity and dyslipidemia was obtained in the clinical and molecular-genetic study the young population of the Republic of Moldova, with implementation of methods of molecular-genetic diagnosis for alleles detection.Genotyping of 9 mononucleotide polymorphisms was performed with the subsequent estimation of the interdependencies between cardiovascular parameters and the genetic risk variants.

The scientific solved problem: consisted of highlighting the impact of mononucleotide polymorphisms on anthropometric and lipidic cardiovascular factors, contributing to the optimization of the risk stratification, the initiation of the prophylactic preventive interventions.

The theoretical significance: The study is a significant scientific support that reflects the clinical, biochemical and genetic particularities of cardiovascular risk factors and allows the development of a diagnostic algorithm for young people in the high risk group.

The applicative value of the thesis: Revealing the usefulness of clinical-biochemical parameters as well as genetic markers will optimize the diagnosis at preclinical stages due to the delineation of the increased cardiovascular risk group, contributing to the improvement of the programs for the estimation of cardiovascular and genetically conditioned risk.

The implementation of the scientific results: The scientific results were implemented in the genetics laboratory and University Clinic, N. Testemitanu SUMPh.