StatusThe thesis was presented on the 27 February, 2019 at the meeting of the Scientific Council and now it is under consideration of the National Council.
Abstract– 0.85 Mb / in romanian
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Structure of the thesis: introduction, 4 chapters, conclusions and recommendations, bibliography from 171 sources, 104 pages, 45 tables, 39 figures. The derived results have been published in 11 scientific papers.
Field of study: Cardiology.
Purpose: studying the contribution of mononucleotide polymorphisms to young people. The trheeseeaxrpcrhesosbijoenctiovfesa:ntShtruodpyoimngettrhice aspnrdealdipoidf acnatrhdrioopvoamsceutlraicr rriisskk ffaaccttoorrss foinr cardiovascular risk; researching the spread and intensity of cardiovascular risk biochemical factors; detecting 9 mononucleotide polymorphisms; the statistical estimation of the association between the polymorphisms determined with the phenotypic manifestations studied.
The novelty and the scientific originality. Original data on the rate of obesity and dyslipidemia was obtained in the clinical and molecular-genetic study the young population of the Republic of Moldova, with implementation of methods of molecular-genetic diagnosis for alleles detection.Genotyping of 9 mononucleotide polymorphisms was performed with the subsequent estimation of the interdependencies between cardiovascular parameters and the genetic risk variants.
The scientific solved problem: consisted of highlighting the impact of mononucleotide polymorphisms on anthropometric and lipidic cardiovascular factors, contributing to the optimization of the risk stratification, the initiation of the prophylactic preventive interventions.
The theoretical significance: The study is a significant scientific support that reflects the clinical, biochemical and genetic particularities of cardiovascular risk factors and allows the development of a diagnostic algorithm for young people in the high risk group.
The applicative value of the thesis: Revealing the usefulness of clinical-biochemical parameters as well as genetic markers will optimize the diagnosis at preclinical stages due to the delineation of the increased cardiovascular risk group, contributing to the improvement of the programs for the estimation of cardiovascular and genetically conditioned risk.
The implementation of the scientific results: The scientific results were implemented in the genetics laboratory and University Clinic, N. Testemitanu SUMPh.